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Article

Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 1999

Cohen L E, Zanger K, Brue T, Wondisford F E, Radovick S

Abstract excerpt

Pit-1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals. Pit-1 contains two protein domains, termed POU-specific and POU-homeo, which are both necessary for DNA binding and activation of the GH and PRL genes and regulation of the...

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Source

Identifiers

PMID: 10077004
DOI: 10.1210/mend.13.3.0251

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10077004-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency.PMID 10077004Read ↗

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[Pituitary development and pathology of transcription factors].Semantic proximity Read ↗

Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.Semantic proximity Read ↗

Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency.Semantic proximity Read ↗

POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease*Semantic proximity Read ↗

[Pituitary specific transcription factor Pit-1/GHF-1 and combined pituitary hormone deficiency].Semantic proximity Read ↗

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