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Article

Regulation of cyclin B2 expression and cell cycle G2/m transition by menin.

The Journal of biological chemistry - 11 Jun 2010

Wu Ting, Zhang Xiuli, Huang Xiaohua, Yang Yuqing, Hua Xianxin

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN1) results from mutations in tumor suppressor gene Men1, which encodes nuclear protein menin. Menin up-regulates certain cyclin-dependent kinase inhibitors through increasing histone H3 lysine 4 (H3K4) methylation and inhibits G(0)/G(1) to S phase transition. However, little is known as to whether menin controls G(2)/M-phase transition, another important cell cycle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20404349
DOI: 10.1074/jbc.M110.106575
PMCID: PMC2881754

Genes

MEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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