Article
Assembly of the inner rod determines needle length in the type III secretion injectisome.
Nature - 1 Jun 2006
Marlovits Thomas C, Kubori Tomoko, Lara-Tejero María, Thomas Dennis, Unger Vinzenz M, Galán Jorge E
Abstract excerpt
Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine is the needle complex or injectisome, an organelle associated with the bacterial envelope that...
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