Article
Identification of the nuclear localization motif in the ETV6 (TEL) protein.
Cancer genetics and cytogenetics - 1 Jun 2006
Park Heesoon, Seo Yoonhee, Kim Jin Il, Kim Wun-jae, Choe Soo Young
Abstract excerpt
ETV6, or Translocation-Ets-Leukemia (TEL), is an ETS family transcriptional repressor that is essential for establishing hematopoiesis in neonatal bone marrow, and is frequently a target of chromosomal translocations in human cancer. ETV6 is predominantly a nuclear phosphoprotein that represses transcription by binding directly to the promoters of target genes. The nuclear localization mechanism of ETV6, however,...
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