Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

doi:10.1016/0006-8993(95)00063-v

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Article

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

Brain research - 3 Apr 1995

Dal Canto M C, Gurney M E

Abstract excerpt

Two different lines of mice, G1 and G20, carrying a transgene for a mutant form of Cu,Zn SOD, found in a family with familial amyotrophic lateral sclerosis (FALS), develop clinical and pathological changes which are, in their late stages, strikingly similar to those in human disease. We have anal...

Topics

Age of Onset
Amyotrophic Lateral Sclerosis
Animals
Brain
Cell Line
Cell Survival
Copper
Disease Models, Animal
Family
Gene Expression
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mitochondria

Mutation

Spinal Cord

Superoxide Dismutase

Zinc

Source

Open in PubMed

Identifiers

PMID: 7796176
DOI: 10.1016/0006-8993(95)00063-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7796176-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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