Article
A protein evolution model with independent sites that reproduces site-specific amino acid distributions from the Protein Data Bank.
BMC evolutionary biology - 31 May 2006
Bastolla Ugo, Porto Markus, Roman H Eduardo, Vendruscolo Michele
Abstract excerpt
BACKGROUND: Since thermodynamic stability is a global property of proteins that has to be conserved during evolution, the selective pressure at a given site of a protein sequence depends on the amino acids present at other sites. However, models of molecular evolution that aim at reconstructing the evolutionary history of macromolecules become computationally intractable if such correlations between sites are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.