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Article

Neutral evolution of protein-protein interactions: a computational study using simple models.

BMC structural biology - 19 Nov 2007

Noirel Josselin, Simonson Thomas

Abstract excerpt

BACKGROUND: Protein-protein interactions are central to cellular organization, and must have appeared at an early stage of evolution. To understand better their role, we consider a simple model of protein evolution and determine the effect of an explicit selection for Protein-protein interactions. RESULTS: In the model, viable sequences all have the same fitness, following the neutral evolution theory. A very...

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Identifiers

PMID: 18021454
DOI: 10.1186/1472-6807-7-79
PMCID: PMC2248192

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