Article
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
Nitric oxide : biology and chemistry - 30 Nov 2016
Kumar Galimudi Rajesh, Spurthi Kondapalli Mrudula, Kumar Gundapaneni Kishore, Aiyengar Tupurani Mohini, Chiranjeevi Padala, Nivas Shyamala, Anuradha Cingeetham, Swathi Banapuram, Sahu Sanjib Kumar, Ali Altaf, Rani Hanumanth Surekha
Abstract excerpt
BACKGROUND: The eNOS gene has been extensively screened for important variations in the promoter (-786T/C), Intron 4 (4b/4a) and exon 7 (894G/T) regions in multiple diseases. Prevalence of Coronary Heart Disease (CHD) is much higher in young Indians when compared to other ethnic groups and first-degree relatives (FDRS) of CHD patients are at risk correlating with earlier age-of-onset and poor prognosis....
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