Article
Clock mutant mice with Jcl/ICR background shows an impaired learning ability in water maze, but not in passive avoidance, at the beginning of dark phase.
Congenital anomalies - 1 Jun 2006
Sei Hiroyoshi, Oishi Katsutaka, Sano Atsuko, Seno Hiromasa, Ohmori Tetsuro, Morita Yusuke, Ishida Norio
Abstract excerpt
We observed the learning ability in Clock mutant mice with Jcl/ICR background (Clockj), a mice model of evening-type individuals, in the early part of dark phase. In order to estimate the learning ability, Morris water maze (WM) and passive avoidance (PA) test were performed. Release of acetylcholine, 5 hydroxytryptophan (5-HT) and dopamine (DA) in hippocampus was measured by in vivo microdialysis method. Clockj...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.