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Article

Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2007

Nagai Jun, Kurokawa Mamoru, Takeshima Hiroshi, Kieffer Brigitte L, Ueda Hiroshi

Abstract excerpt

Using the novel apparatus KUROBOX, learning and memory behaviors, as well as various parameters of movement activity, were reevaluated in mice deficient for nociceptin/orphanin FQ receptor (NOP-/- mice) or mu-opioid receptor (MOP-/- mice). This method has the advantages that no handling procedures are required throughout the experiments performed over 3 days, positive cue paradigms are used without water or shock...

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Identifiers

PMID: 17209168
DOI: 10.1124/jpet.106.115121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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