Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The NS2 Protein of Human Respiratory Syncytial Virus Suppresses the Cytotoxic T-Cell Response as a Consequence of Suppressing the Type I Interferon Response

26 May 2006

Abstract excerpt

The NS1 and NS2 proteins of human respiratory syncytial virus (HRSV) have been shown to antagonize the type I interferon (IFN) response, an effect subject to host range constraints. We have now found that the HRSV NS2 protein strongly controls IFN induction in mouse cells in vitro, validating the use of the mouse model to study the consequences of these gene deletions on host immunity. We evaluated the effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to interferon and immune responses
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16731934
DOI: 10.1128/jvi.00181-06

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NS2 Protein of Human Respiratory Syncytial Virus Suppresses the Cytotoxic T-Cell Response as a Consequence of Suppressing the Type I Interferon ResponsePMID 16731934Read ↗

Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected].Semantic proximity Read ↗

Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway.Semantic proximity Read ↗

Effects of Nonstructural Proteins NS1 and NS2 of Human Respiratory Syncytial Virus on Interferon Regulatory Factor 3, NF-κB, and Proinflammatory CytokinesSemantic proximity Read ↗

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.Semantic proximity Read ↗

Both Nonstructural Proteins NS1 and NS2 of Pneumonia Virus of Mice are Inhibitors of the Interferon Type I and Type III Responses In VivoSemantic proximity Read ↗

Respiratory Syncytial Virus (RSV) Nonstructural (NS) Proteins as Host Range Determinants: a Chimeric Bovine RSV with NS Genes from Human RSV Is Attenuated in Interferon-Competent Bovine CellsSemantic proximity Read ↗

Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2Semantic proximity Read ↗

Cell-Type-Specific Type I Interferon Antagonism Influences Organ Tropism of Murine CoronavirusSemantic proximity Read ↗

Distinct types of lung disease caused by functional subsets of antiviral T cells.Semantic proximity Read ↗

The role of IFN in respiratory syncytial virus pathogenesis.Semantic proximity Read ↗

The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus.Semantic proximity Read ↗

Influence of a single viral epitope on T cell response and disease after infection of mice with respiratory syncytial virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.