Article
Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.
Nature microbiology - 30 Jun 2017
Chatterjee Srirupa, Luthra Priya, Esaulova Ekaterina, Agapov Eugene, Yen Benjamin C, Borek Dominika M, Edwards Megan R, Mittal Anuradha, Jordan David S, Ramanan Parameshwar, Moore Martin L, Pappu Rohit V, Holtzman Michael J, Artyomov Maxim N, Basler Christopher F, Amarasinghe Gaya K, Leung Daisy W
Abstract excerpt
Human respiratory syncytial virus (hRSV) is a major cause of morbidity and mortality in the paediatric, elderly and immune-compromised populations1,2. A gap in our understanding of hRSV disease pathology is the interplay between virally encoded immune antagonists and host components that limit hRSV replication. hRSV encodes for non-structural (NS) proteins that are important immune antagonists3-6; however, the...
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