The colR4 and colR15 beta-tubulin mutations in Chlamydomonas reinhardtii confer altered sensitivities to microtubule inhibitors and herbicides by enhancing microtubule stability.

doi:10.1083/jcb.113.3.605

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Article

The colR4 and colR15 beta-tubulin mutations in Chlamydomonas reinhardtii confer altered sensitivities to microtubule inhibitors and herbicides by enhancing microtubule stability.

The Journal of cell biology - 1 May 1991

Schibler M J, Huang B

Abstract excerpt

The colR4 and colR15 beta 2-tubulin missense mutations for lysine-350 in Chlamydomonas reinhardtii (Lee and Huang, 1990) were originally isolated by selection for resistance to the growth inhibitory effects of colchicine. The colR4 and colR15 mutants have been found to be cross resistant to vinbl...

Topics

Acetylation
Alkaloids
Chlamydomonas
Colchicine
Drug Resistance
Herbicides
Microscopy, Electron
Microtubules
Mutation
Paclitaxel
Spindle Apparatus
Tubulin
Vinblastine

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