A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii confers resistance to anti-microtubule herbicides.

doi:10.1242/jcs.106.1.209

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Article

A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii confers resistance to anti-microtubule herbicides.

Journal of cell science - 1 Sept 1993

James S W, Silflow C D, Stroom P, Lefebvre P A

Abstract excerpt

A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii was isolated by using the amiprophos-methyl-resistant mutation apm1-18 as a background to select new mutants that showed increased resistance to the drug. The upA12 mutation caused twofold resistance to amiprophos-methyl and oryzalin, and twofold hypersensitivity to the microtubule-stabilizing drug taxol, suggesting that the mutation enhanced...

Topics

Acetylation
Alleles
Animals
Chlamydomonas reinhardtii
DNA Mutational Analysis
Dinitrobenzenes
Drug Resistance
Genes, Plant
Genes, Protozoan
Microtubules
Nitrobenzenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organothiophosphorus Compounds

Paclitaxel

Plant Proteins

Protein Processing, Post-Translational

Protozoan Proteins

Sulfanilamides

Tubulin

Source

Open in PubMed

Identifiers

PMID: 7903670
DOI: 10.1242/jcs.106.1.209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7903670-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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