Article
Tryptophan analog resistance mutations in Chlamydomonas reinhardtii.
Genetics - 1 Jul 1992
Dutcher S K, Galloway R E, Barclay W R, Poortinga G
Abstract excerpt
Forty single gene mutations in Chlamydomonas reinhardtii were isolated based on resistance to the compound 5'-methyl anthranilic acid (5-MAA). In other organisms, 5-MAA is converted to 5'-methyltryptophan (5-MT) and 5-MT is a potent inhibitor of anthranilate synthase, which catalyzes the first committed step in tryptophan biosynthesis. The mutant strains fall into two phenotypic classes based on the rate of cell...
Topics
- Animals
- Chlamydomonas reinhardtii
- Chromosome Mapping
- Drug Resistance
- Drug Resistance, Microbial
- Genes, Dominant
- Indoles
- Mutation
- Phenotype
- Tryptophan
- ortho-Aminobenzoates