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Article

Tryptophan analog resistance mutations in Chlamydomonas reinhardtii.

Genetics - 1 Jul 1992

Dutcher S K, Galloway R E, Barclay W R, Poortinga G

Abstract excerpt

Forty single gene mutations in Chlamydomonas reinhardtii were isolated based on resistance to the compound 5'-methyl anthranilic acid (5-MAA). In other organisms, 5-MAA is converted to 5'-methyltryptophan (5-MT) and 5-MT is a potent inhibitor of anthranilate synthase, which catalyzes the first committed step in tryptophan biosynthesis. The mutant strains fall into two phenotypic classes based on the rate of cell...

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Identifiers

PMID: 1628807
DOI: 10.1093/genetics/131.3.593
PMCID: PMC1205033

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