Article
Uncovering a hidden distributed architecture behind scale-free transcriptional regulatory networks.
Journal of molecular biology - 30 Jun 2006
Balaji S, Iyer Lakshminarayan M, Aravind L, Babu M Madan
Abstract excerpt
Numerous studies in both prokaryotes and eukaryotes have shown that, under standard growth conditions, less than 20% of the protein-coding genes are essential for survival. This suggests that biological systems have evolved to have a high degree of robustness to mutational disruptions that can affect the majority of their genes. This mutational robustness could arise either due to redundancy, i.e. direct backup,...
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