Circadian clocks go in vitro: purely post-translational oscillators in cyanobacteria.

doi:10.1038/msb4100027

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Article

Circadian clocks go in vitro: purely post-translational oscillators in cyanobacteria.

Molecular systems biology - 1 Jan 2005

Naef Felix

Abstract excerpt

Recent findings about the core of the circadian oscillator in cyanobacteria are challenging the dogma that such clocks are driven through transcriptional-translational feedback regulation. Instead, the master pacemaker is independent of both transcription and translation, and consists of self-sustained oscillations in the phosphorylation status of the KaiC protein in vivo. Using a minimal cocktail of three...

Topics

Adenosine Triphosphate
Animals
Arabidopsis
Arabidopsis Proteins
Bacterial Proteins
Biological Clocks
Cell-Free System
Circadian Rhythm
Circadian Rhythm Signaling Peptides and Proteins
Cyanobacteria
Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drosophila melanogaster

Feedback, Physiological

Gene Expression Regulation

Mammals

Models, Biological

Phenotype

Protein Biosynthesis

Source

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Identifiers

PMID: 16729054
DOI: 10.1038/msb4100027
PMCID: PMC1681462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16729054-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Circadian clocks go in vitro: purely post-translational oscillators in cyanobacteria.PMID 16729054Read ↗

Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro.Semantic proximity Read ↗

Reconstitution of an intact clock reveals mechanisms of circadian timekeeping.Semantic proximity Read ↗

ATPase activity of KaiC determines the basic timing for circadian clock of cyanobacteria.Semantic proximity Read ↗

No transcription-translation feedback in circadian rhythm of KaiC phosphorylation.Semantic proximity Read ↗

Intrinsic period stability of the cyanobacterial circadian oscillator across in vitro and in vivo conditions.Semantic proximity Read ↗

Revealing a two-loop transcriptional feedback mechanism in the cyanobacterial circadian clock.Semantic proximity Read ↗

Diversity of KaiC-based timing systems in marine Cyanobacteria.Semantic proximity Read ↗

Transcriptional autoregulation by phosphorylated and non-phosphorylated KaiC in cyanobacterial circadian rhythms.Semantic proximity Read ↗

KaiA-stimulated KaiC phosphorylation in circadian timing loops in cyanobacteria.Semantic proximity Read ↗

Tuning the circadian period of cyanobacteria up to 6.6 days by the single amino acid substitutions in KaiC.Semantic proximity Read ↗

The recovery of KaiA's activity depends on its N-terminal domain and KaiB in the cyanobacterial circadian clock.Semantic proximity Read ↗

Intramolecular regulation of phosphorylation status of the circadian clock protein KaiC.Semantic proximity Read ↗

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