Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gender and age effects on ventricular repolarization abnormality in Japanese general carriers of a G643S common single nucleotide polymorphism for the KCNQ1 gene.

Circulation journal : official journal of the Japanese Circulation Society - 1 Jun 2006

Ozawa Tomoya, Ito Makoto, Tamaki Shinji, Yao Takenori, Ashihara Takashi, Kita Yoshikuni, Okamura Tomonori, Ueshima Hirotsugu, Horie Minoru

Abstract excerpt

BACKGROUND: The KCNQ1 single nucleotide polymorphism (SNP), G643S, is known to be associated with secondary long QT syndrome (LQTS) and to cause a mild reduction in KCNQ1 current. However, the precise incidence and its association with QT intervals remain unknown in the greater cohort of the population in Japan. METHODS AND RESULTS: The genotype was screened at codon 643 of KCNQ1 in 992 residents of a farming...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Cohort Studies

Share to KCNQ1 Potassium Channel

Share to Long QT Syndrome

Share to Sex Factors

Source

Identifiers

PMID: 16723781
DOI: 10.1253/circj.70.645

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gender and age effects on ventricular repolarization abnormality in Japanese general carriers of a G643S common single nucleotide polymorphism for the KCNQ1 gene.PMID 16723781Read ↗

Evidence for a single nucleotide polymorphism in the KCNQ1 potassium channel that underlies susceptibility to life-threatening arrhythmias.Semantic proximity Read ↗

Genotype-dependent differences in age of manifestation and arrhythmia complications in short QT syndrome.Semantic proximity Read ↗

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype.Semantic proximity Read ↗

Genetic Modifiers for the Long-QT Syndrome: How Important Is the Role of Variants in the 3' Untranslated Region of KCNQ1?Semantic proximity Read ↗

Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants.Semantic proximity Read ↗

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.Semantic proximity Read ↗

Clinical value of electrocardiographic parameters in genotyped individuals with familial long QT syndrome.Semantic proximity Read ↗

Cardiac Mechanical Alterations and Genotype Specific Differences in Subjects With Long QT Syndrome.Semantic proximity Read ↗

The phenotype characteristics of type 13 long QT syndrome with mutation in KCNJ5 (Kir3.4-G387R).Semantic proximity Read ↗

Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations.Semantic proximity Read ↗

A Common Mutation of Long QT Syndrome Type 1 in Japan.Semantic proximity Read ↗

Common candidate gene variants are associated with QT interval duration in the general population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.