Article
The phenotype characteristics of type 13 long QT syndrome with mutation in KCNJ5 (Kir3.4-G387R).
Heart rhythm - 1 Oct 2013
Wang Fan, Liu Jinqiu, Hong Li, Liang Bo, Graff Claus, Yang Yanzong, Christiansen Michael, Olesen Søren-Peter, Zhang Li, Kanters Jørgen K
Abstract excerpt
BACKGROUND: Long QT syndrome type 13 (LQT13) is caused by loss-of-function mutation in the KCNJ5-encoded cardiac G-protein-coupled inward rectifier potassium channel subtype 4 protein. The electrocardiographic (ECG) features of LQT13 are not described yet. OBJECTIVE: To describe for the first time in detail the phenotype-genotype relationship of the ECG and clinical features in patients with LQT13. METHODS: The...
Topics
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Electrocardiography, Ambulatory
- Female
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- Genotype
- Heart Rate
- Humans
- Infant, Newborn
- Long QT Syndrome
- Male
- Middle Aged