Article
DNA sequence differences of ampD mutants of Citrobacter freundii.
Antimicrobial agents and chemotherapy - 1 Nov 1995
Stapleton P, Shannon K, Phillips I
Abstract excerpt
Three groups of mutants with increased levels of beta-lactamase synthesis were selected from Citrobacter freundii 382010 by beta-lactam antibiotics at concentrations just above the MIC. Uninduced cultures of the hyperinducible group had 3- to 5-fold more beta-lactamase activity than the parent strain, with one mutant (termed type b) expressing 19 times the activity of the parent strain; the partially derepressed...
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