Article
Estrogen receptor polymorphisms in tamoxifen-treated women with breast cancer.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 1 Apr 2006
Georgopoulos Neoklis A, Adonakis George L, Fotopoulos Andreas, Koika Vasiliki, Spinos Nikitas, Saltamavros Alexandros, Keramopoulos Antonios, Koukouras Dimitrios, Decavalas George, Kourounis George S
Abstract excerpt
In postmenopausal women with estrogen receptor (ER)-positive breast cancer, long-term tamoxifen administration has proved beneficial after surgical treatment and subsequent chemotherapy. One of the major adverse effects of tamoxifen is the development of endometrial pathology (polyps, endometrial hyperplasia and endometrial cancer). PvuII and XbaI polymorphisms of the estrogen receptor-alpha gene (ERalpha) and...
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