Article
Estrogen receptor alpha (ER-alpha) gene polymorphism in patients from the Lodz region of Poland with sporadic endometrial cancer.
European journal of gynaecological oncology - 1 Jan 2009
Sobczuk A, Smolarz B, Romanowicz-Makowska H, Pertyński T
Abstract excerpt
OBJECTIVE: Estrogens play a crucial role in the pathogenesis and progression of endometrial cancer. The gene ER-alpha is polymorphic and gene variability could contribute to the level of protein biosynthesis. METHODS: The aim of this study was to evaluate PvuII and XbaI polymorphism of the ER-alpha gene in 120 postmenopausal women with endometrial cancer in DNA samples obtained from cancer tissue. The...
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