Article
Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population.
Genetics and molecular research : GMR - 27 Oct 2014
Quintero-Ramos A, Gutiérrez-Rubio S A, Del Toro-Arreola A, Franco-Topete R A, Oceguera-Villanueva A, Jiménez-Pérez L M, Castro-Cervantes J M, Barragán-Ruiz A, Vázquez-Camacho J G, Daneri-Navarro A
Abstract excerpt
Breast cancer (BC) is the leading cause of cancer-related deaths among women in Mexico. Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5'-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3'-untranslated region (TS 3'-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to...
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