Article
Mannose-binding lectin-2 genetic variation and stomach cancer risk.
International journal of cancer - 15 Oct 2006
Baccarelli Andrea, Hou Lifang, Chen Jinbo, Lissowska Jolanta, El-Omar Emad M, Grillo Paolo, Giacomini Sara M, Yaeger Meredith, Bernig Toralf, Zatonski Witold, Fraumeni Joseph F, Chanock Stephen J, Chow Wong-Ho
Abstract excerpt
Deficiency of the mannose-binding lectin (MBL) protein, an antigen-recognition molecule involved in systemic and mucosal innate immunity, is determined by variant alleles in MBL2 gene promoter and exon-1 regions. We conducted a population-based study on 305 stomach cancer cases and 427 controls in Warsaw, Poland to determine whether MBL2 gene variants predispose to stomach cancer. Single nucleotide polymorphisms...
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