Article
Mannan-binding lectin B allele is associated with a risk of developing more severe gastric mucosal atrophy in Helicobacter pylori-infected Japanese patients.
European journal of gastroenterology & hepatology - 1 Jul 2009
Tahara Tomomitsu, Shibata Tomoyuki, Wang Fang-Yu, Nakamura Masakatsu, Yamashita Hiromi, Yoshioka Daisuke, Okubo Masaaki, Maruyama Naoko, Kamiya Yoshio, Nakamura Masahiko, Fujita Hiroshi, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Nakano Hiroshi, Hirata Ichiro, Arisawa Tomiyasu
Abstract excerpt
OBJECTIVE: Mannan-binding lectin (MBL) is an important constituent of the innate immune system, and deficiency of MBL has been reported to increase the overall susceptibility of an individual to infectious disease. Codon 54 G/A variant of exon 1 (B allele) affects MBL2 gene and alters its activit...
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