Article
HLA-DR and DQ DNA genotyping in multiple sclerosis patients in Northern Ireland.
Human immunology - 1 Jan 1991
Cullen C G, Middleton D, Savage D A, Hawkins S
Abstract excerpt
DNA from multiple sclerosis (MS) patients and healthy control individuals from the Northern Ireland population, was assessed by restriction fragment length polymorphism (RFLP) analysis to look for disease-associated polymorphisms. HLA-DR and -DQ allogenotyping was performed using a single enzyme (TaqI)/Multiple probe system. The TaqI/DR beta RFLPs correlate well with serologically defined specificities and in...
Topics
- Gene Frequency
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Multiple Sclerosis
- Polymorphism, Restriction Fragment Length