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Article

Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN.

Frontiers in bioscience : a journal and virtual library - 1 Sept 2006

Andrés Vicente, Gascón-Irún Marisol, Pandolfi Pier Paolo, González-Navarro Herminia

Abstract excerpt

PTEN is a dual-specificity phosphatase that has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation and migration, two key events in the ethiopathogenesis of atherosclerosis. Adenovirus-mediated PTEN overexpression inhibited the formation of vascular obstructive lesions induced by mechanical injury of the vessel wall. In this study, we investigated whether PTEN protects against atheroma...

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Source

Identifiers

PMID: 16720346
DOI: 10.2741/2003

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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