Roles of the Werner syndrome protein in pathways required for maintenance of genome stability.

doi:10.1016/s0531-5565(01)00227-3

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Article

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability.

Experimental gerontology - 1 Apr 2002

Brosh Robert M, Bohr Vilhelm A

Abstract excerpt

Werners syndrome is a disease of premature aging where the patients appear much older than their chronological age. The gene codes for a protein that is a helicase and an exonuclease, and recently we have learned about some of its protein interactions. These interactions are being discussed as they shed light on the molecular pathways in which Werner protein participates. Insight into these pathways brings...

Topics

Catalysis
Chromosome Aberrations
DNA Helicases
DNA Replication
Exodeoxyribonucleases
Humans
Mutation
Phenotype
Polymorphism, Genetic
RecQ Helicases
Tumor Suppressor Protein p53
Werner Syndrome
Werner Syndrome Helicase

Source

Open in PubMed

Identifiers

PMID: 11830352
DOI: 10.1016/s0531-5565(01)00227-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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