Proteasomal dysfunction in sporadic Parkinson's disease.

Abstract excerpt

The cause and mechanism of neuronal death in sporadic Parkinson's disease (PD) continue to elude investigators. Recently, alterations in proteasomal function have been detected in the brain of patients with the illness. The biochemical basis of the defect and its relevance to the disease process are now being studied. The available results suggest that proteasomal dysfunction could underlie protein accumulation,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Brain
• Share to Genetic Predisposition to Disease
• Share to Models, Neurological