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Article

Brain proteasomal function in sporadic Parkinson's disease and related disorders

3 May 2002

Abstract excerpt

Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12112087
DOI: 10.1002/ana.10207

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