Article
Structural diversity in the Plasmodium falciparum merozoite surface antigen 2.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1991
Smythe J A, Coppel R L, Day K P, Martin R K, Oduola A M, Kemp D J, Anders R F
Abstract excerpt
Antigens associated with the surface of merozoites of the malaria parasite Plasmodium falciparum are directly accessible to immune attack and therefore are prime vaccine candidates. We have previously shown that one of the two known merozoite surface antigens (merozoite surface antigen 2; MSA-2) exhibits considerable sequence and antigenic diversity in different isolates. The sequences of MSA-2 from three...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Protozoan
- Antigens, Surface
- Base Sequence
- Genes
- Genetic Variation
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Oligonucleotide Probes