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Article

Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity.

Biochemical and biophysical research communications - 19 Aug 2011

Zhou Fangfang, Gong Kai, van Laar Theo, Gong Yandao, Zhang Long

Abstract excerpt

Amyloid precursor protein (APP), a key protein in pathogenesis of Alzheimer's disease (AD), is a type I transmembrane protein which can be cleaved by β- and γ-secretase to release the amyloidogenic β-amyloid peptides (Aβ) and the APP intracellular domain (AICD). While Aβ has been widely believed to initiate pathogenic cascades culminating AD, the physiological functions and regulations of AICD remain elusive. In...

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Source

Identifiers

PMID: 21798242
DOI: 10.1016/j.bbrc.2011.07.040

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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