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Article

Investigating the structural dependence of protein stabilization by amino acid substitution.

Biochemistry - 23 Apr 2013

Tadokoro Takashi, Kazama Hirotaka, Koga Yuichi, Takano Kazufumi, Kanaya Shigenori

Abstract excerpt

A goal of protein engineering technology is developing methods to increase protein stability. However, rational design of stable proteins is difficult because the stabilization mechanism of proteins is not fully understood. In this study, we examined the structural dependence of protein stabilization by introducing single amino acid substitution into ribonuclease H1 from the psychotropic bacterium Shewanella...

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PMID: 23547982
DOI: 10.1021/bi400076f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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