Article
Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila.
Current biology : CB - 23 May 2006
Seidner Glen A, Ye Yihong, Faraday Martha M, Alvord W Gregory, Fortini Mark E
Abstract excerpt
To assess the potential of Drosophila to analyze clinically graded aspects of human disease, we developed a transgenic fly model to characterize Presenilin (PS) gene mutations that cause early-onset familial Alzheimer's disease (FAD). FAD exhibits a wide range in severity defined by ages of onset from 24 to 65 years . PS FAD mutants have been analyzed in mammalian cell culture, but conflicting data emerged...
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