Article
Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan.
Breast (Edinburgh, Scotland) - 1 Dec 2006
Chang Tsai-Wang, Wang Shuei-Ming, Guo Yue-Liang L, Tsai Pei-Chien, Huang Chien-Jung, Huang Wenya
Abstract excerpt
In this study, the genetic polymorphisms associated with breast cancer in southern Taiwan were investigated. Two categories of genes were analyzed: (1) BRCA1, BRCA2, and Rad51, the DNA repair factors involved in homologous recombinational repair; and (2) CYP1A1, COMT, GST, and NAT2, the xenobiotic-metabolizing enzymes (XME) involved in estrogen metabolism. We found that the number of deletions and/or mutations in...
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