Article
Detection and relevance of germline genetic polymorphisms in glutathione S-transferases (GSTs) in breast cancer patients from northern Indian population.
Breast cancer research and treatment - 1 Jun 2009
Saxena Anubha, Dhillon Varinderpal S, Raish Mohammad, Asim Mohammad, Rehman Shabeena, Shukla N K, Deo S V S, Ara Anjum, Husain Syed Akhtar
Abstract excerpt
INTRODUCTION: Glutathione S-transferases (GSTs) are polymorphic superfamily of detoxification enzymes that detoxify therapeutic drugs and various carcinogens. We undertook a case-control study in northern Indian population based sample consisting of 413 patients and 410 controls to evaluate association of null genotype in GSTM1 and GSTT1 along with polymorphism in GSTP1 (A-->G) with breast cancer risk. METHODS:...
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