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Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.

BMC genetics - 18 May 2006

Nakamoto Kaori, Wang Shuang, Jenison Robert D, Guo Grace L, Klaassen Curtis D, Wan Yu-Jui Yvonne, Zhong Xiao-bo

Abstract excerpt

BACKGROUND: Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol and bile acids, including hypercholesterolemia, hypertriglyceridemia, arteriosclerosis, and gallstone disease. Current genetic studies are focused mainly on analysis of a single nucleotide...

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Identifiers

PMID: 16709249
DOI: 10.1186/1471-2156-7-29
PMCID: PMC1488870

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