Article
Allele-specific activation of genetically engineered receptors.
The Journal of biological chemistry - 5 Jan 1991
Strader C D, Gaffney T, Sugg E E, Candelore M R, Keys R, Patchett A A, Dixon R A
Abstract excerpt
The binding of agonists and antagonists to the beta-adrenergic receptor (beta AR) is postulated to involve an ionic interaction between the amine group of the ligand and the carboxylate side chain of Asp113 in the third hydrophobic domain of the receptor. To explore the importance of this interaction in the binding of ligands to the beta AR, a Ser residue was substituted for Asp113, and the ability of this mutant...
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