Article
Involvement of specific hydrophobic, but not hydrophilic, amino acids in the third intracellular loop of the beta-adrenergic receptor in the activation of Gs.
Molecular pharmacology - 1 Jun 1992
Cheung A H, Huang R R, Strader C D
Abstract excerpt
Mutagenesis and biochemical analysis have indicated that amino acid residues at the amino terminus of the third intracellular loops of guanine nucleotide-binding protein (G protein)-coupled receptors are important in mediating the coupling of the receptors to G proteins. Because the primary sequence of this region is not conserved among all receptors that couple to the same G protein, it has been suggested that...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Amino Acids
- Animals
- CHO Cells
- Chemical Phenomena
- Chemistry, Physical
- Cricetinae
- Enzyme Activation
- GTP-Binding Proteins
- Gene Expression