Article
Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996
Wieland K, Zuurmond H M, Krasel C, Ijzerman A P, Lohse M J
Abstract excerpt
To investigate the molecular mechanism for stereospecific binding of agonists to beta 2-adrenergic receptors we used receptor models to identify potential binding sites for the beta-OH-group of the ligand, which defines the chiral center. Ser-165, located in transmembrane helix IV, and Asn-293, situated in the upper half of transmembrane helix VI, were identified as potential binding sites. Mutation of Ser-165 to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.