Article
Multiplex PCR-pyrosequencing assay for genotyping CYP3A5 polymorphisms.
Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2006
Aquilante Christina L, Langaee Taimour Y, Anderson Peter L, Zineh Issam, Fletcher Courtney V
Abstract excerpt
BACKGROUND: The cytochrome P450 (CYP) 3A5 enzyme contributes to the metabolism of many drugs. Single nucleotide polymorphisms in the CYP3A5 gene (CYP3A5(*)3C and CYP3A5(*)6) are associated with decreased CYP3A5 expression in the liver. We designed a multiplex genotyping assay to detect the CYP3A5...
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