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Article

Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency.

Journal of virology - 1 Jun 2006

Kanno Toru, Kim Kisoon, Kono Ken, Drescher Kristen M, Chapman Nora M, Tracy Steven

Abstract excerpt

Group B coxsackieviruses can initiate rapid onset type 1 diabetes (T1D) in old nonobese diabetic (NOD) mice. Inoculating high doses of poorly pathogenic CVB3/GA per mouse initiated rapid onset T1D. Viral protein was detectable in islets shortly after inoculation in association with beta cells as well as other primary islet cell types. The virulent strain CVB3/28 replicated to higher titers more rapidly than...

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Identifiers

PMID: 16699045
DOI: 10.1128/JVI.02361-05
PMCID: PMC1472143

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