Article
Tumor necrosis factor (TNF)-α- 308 G/A gene polymorphism (rs1800629) in Egyptian patients with alopecia areata and vitiligo, a laboratory and in silico analysis.
PloS one - 1 Jan 2020
Abd El-Raheem Talal, Mahmoud Rania H, Hefzy Enas M, Masoud Mohamed, Ismail Reham, Aboraia Nesreen M M
Abstract excerpt
PURPOSE & METHODS: Several single-nucleotide polymorphisms (SNPs) in the promoter region of the TNF-α gene can cause variations in the gene regulatory sites and act as risk factors for some autoimmune disorders as alopecia areata (AA) and vitiligo. This study aimed to detect the serum TNF-α (sTNF) level (by ELISA) and the rs1800629 (by real-time PCR) among AA and vitiligo Egyptian patients and to determine their...
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