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Article

Comment on "Evidence for positive epistasis in HIV-1".

Science (New York, N.Y.) - 12 May 2006

Wang Kai, Mittler John E, Samudrala Ram

Abstract excerpt

Bonhoeffer et al. (Reports, 26 November 2004, p. 1547) presented evidence for positive epistasis in a clinical data set of HIV-1 mutants and corresponding fitness values. We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous...

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PMID: 16690844
DOI: 10.1126/science.1109904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16690844-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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