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Article

Comment on "Evidence for positive epistasis in HIV-1".

Science (New York, N.Y.) - 12 May 2006

Wang Kai, Mittler John E, Samudrala Ram

Abstract excerpt

Bonhoeffer et al. (Reports, 26 November 2004, p. 1547) presented evidence for positive epistasis in a clinical data set of HIV-1 mutants and corresponding fitness values. We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous statistical tests must be used to account for such biases before one can infer epistasis.

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Identifiers

PMID: 16690844
DOI: 10.1126/science.1109904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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