Dissecting the role of protein-protein and protein-nucleic acid interactions in MS2 bacteriophage stability.

doi:10.1111/j.1742-4658.2006.05167.x

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Article

Dissecting the role of protein-protein and protein-nucleic acid interactions in MS2 bacteriophage stability.

The FEBS journal - 1 Apr 2006

Lima Sheila M B, Vaz Ana Carolina Q, Souza Theo L F, Peabody David S, Silva Jerson L, Oliveira Andréa C

Abstract excerpt

To investigate the role of protein-protein and protein-nucleic acid interactions in virus assembly, we compared the stabilities of native bacteriophage MS2, virus-like particles (VLPs) containing nonviral RNAs, and an assembly-defective coat protein mutant (dlFG) and its single-chain variant (sc-dlFG). Physical (high pressure) and chemical (urea and guanidine hydrochloride) agents were used to promote virus...

Topics

Anilino Naphthalenesulfonates
DNA, Viral
Fluorescent Dyes
Guanidine
Hot Temperature
Levivirus
Macromolecular Substances
Mutation
Nucleic Acid Conformation
Protein Conformation
Protein Denaturation
Urea
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 16689932
DOI: 10.1111/j.1742-4658.2006.05167.x

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