Article
Deciphering the Thermal Stability of Bacteriophage MS2-Derived Virus-like Particle and Its Engineered Variant.
ACS biomaterials science & engineering - 12 Aug 2024
Vishwakarma Pragati, Puri Sarita, Banerjee Manidipa, Chang Chia-Yu, Chang Chia-Ching, Chaudhuri Tapan K
Abstract excerpt
RNA bacteriophage MS2-derived virus-like particles (VLPs) have been widely used in biomedical research as model systems to study virus assembly, structure-function relationships, vaccine development, and drug delivery. Considering the diverse utility of these VLPs, a systemic engineering approach has been utilized to generate smaller particles with optimal serum stability and tissue penetrance. Additionally, it...
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