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Article

Complement Recognition Pathways in Renal Transplantation

29 Jun 2017

Abstract excerpt

The complement system, consisting of soluble and cell membrane-bound components of the innate immune system, has defined roles in the pathophysiology of renal allograft rejection. Notably, the unavoidable ischemia-reperfusion injury inherent to transplantation is mediated through the terminal complement activation products C5a and C5b-9. Furthermore, biologically active fragments C3a and C5a, produced during...

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PMID: 28663231
DOI: 10.1681/asn.2017010079

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