Article
The human papillomavirus type 11 E1/\E4 protein is not essential for viral genome amplification.
Virology - 1 Aug 2006
Fang L, Budgeon L R, Doorbar J, Briggs E R, Howett M K
Abstract excerpt
An abundant human papillomavirus (HPV) protein E1/\E4 is expressed late in the virus life cycle in the terminally differentiated layers of epithelia. The expression of E1/\E4 usually coincides with the onset of viral DNA amplification. However, the function of E1/\E4 in viral life cycle is not completely understood. To examine the role of E1/\E4 in the virus life cycle, we introduced a single nucleotide change in...
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