Article
Mutations in HPV18 E1^E4 Impact Virus Capsid Assembly, Infectivity Competence, and Maturation.
Viruses - 19 Dec 2017
Biryukov Jennifer, Myers Jocelyn C, McLaughlin-Drubin Margaret E, Griffin Heather M, Milici Janice, Doorbar John, Meyers Craig
Abstract excerpt
The most highly expressed protein during the productive phase of the human papillomavirus (HPV) life cycle is E1^E4. Its full role during infection remains to be established. HPV E1^E4 is expressed during both the early and late stages of the virus life cycle and contributes to viral genome amplification. In an attempt to further outline the functions of E1^E4, and determine whether it plays a role in viral...
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