Patterned Purkinje cell death in the cerebellum.

Abstract excerpt

The object of this review is to assemble much of the literature concerning Purkinje cell death in cerebellar pathology and to relate this to what is now known about the complex topography of the cerebellar cortex. A brief introduction to Purkinje cells, and their regionalization is provided, and then the data on Purkinje cell death in mouse models and, where appropriate, their human counterparts, have been...

Topics

• Animals
• Cell Death
• Cerebellar Cortex
• Cerebellum
• Disease Models, Animal
• Humans
• Mice
• Mutation
• Neurotoxins
• Purkinje Cells
• Receptors, Glutamate